|(6S,7S,12aR)-1,2,3,10,11,12-六甲氧基-6,7-二甲基-5,6,7,8-四氢二苯并[a,c][8]轮烯-6-醇|CsnPharm

CAS No.: 7432-28-2

五味子醇甲 Catalog No. CSN19434

Synonyms: Schizandrin;Schizandrol;Schizandrol-A

Schizandrin is a natural product possessing antioxidant and anti-inflammatory activities.

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生物活性

实验方案

技术信息

生物活性

描述Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) Baill with antioxidant and anti-inflammatory properties. Schizandrin prevented LPS-induced injury in the H9c2 cells and promoted the recovery of myocardial tissues by enhancing cell viability and migration^[3]. Sch A specifically reverses P-gp-mediated DOX resistance in MCF-7/DOX cells by blocking P-gp, NF-κB, and Stat3 signaling. Inhibition of P65 and Stat3 shows potent anti-MDR (Multidrug resistance) effect on MCF-7/DOX cells^[4]. Schizandrin (1 and 10 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of spatial memory. Similarly, schizandrin (1 mg/kg, p.o.) significantly reversed the scopolamine-induced impairment of the passive avoidance response. Moreover, in mice, schizandrin (1 and 10 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist^[5]. Pretreatment of the cortical cell cultures with schizandrin (10, 100 microM) for 2 h significantly protected cortical neurons against Glu-induced excitotoxicity. The neuroprotective activity of schizandrin was the most potent at the concentration of 100 microM. In addition, schizandrin diminished the intracellular Ca2+ influx, inhibited the subsequent overproduction of nitric oxide (NO), reactive oxygen species (ROS), and cytochrome c, and preserved the mitochondrial membrane potential. Furthermore, schizandrin also increased the cellular level of glutathione (GSH) and inhibited the membrane lipid peroxidation malondialdehyde (MDA)^[6]. Schizandrin can be used to treat inflammatory and atopic diseases through the inhibition of TSLP(Thymic stromal lymphopoietin) ^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02185638	Obesity	Not Applicable	Completed	-	Denmark ... more >> Department Of Human Nutrition, Faculty of Science, University of Copenhagen Frederiksberg, Denmark, 1958 Collapse <<
NCT02298426	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	China, Beijing ... more >> Peking University Health Science Center Peking, Beijing, China, 100191 Collapse <<
NCT00676975	Irritable Bowel Syndrome	Phase 2	Completed	-	China ... more >> Li Ka Shing Specialist Clinic, Prince of Wales Hospital Hong Kong (SAR), China, 852 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3121 mL
- 11.5605 mL
- 23.1210 mL
- 5 mM
- 0.4624 mL
- 2.3121 mL
- 4.6242 mL
- 10 mM
- 0.2312 mL
- 1.1561 mL
- 2.3121 mL

技术信息

CAS号

7432-28-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H32O7

运输

蓝冰

分子量

432.51

别名

Schizandrin;Schizandrol;Schizandrol-A;Wuweizi Alcohol-A;Wuweizichun A;(+)-Schizandrin;Gomisins;Magnolia Vine;Omija;Schisandrol A;Wuweizins;五味子醇甲

溶解度

DMSO	150.0 mg/mL (346.8 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02185638	Obesity	Not Applicable	Completed	-	Denmark ... more >> Department Of Human Nutrition, Faculty of Science, University of Copenhagen Frederiksberg, Denmark, 1958 Collapse <<
NCT02298426	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	China, Beijing ... more >> Peking University Health Science Center Peking, Beijing, China, 100191 Collapse <<
NCT00676975	Irritable Bowel Syndrome	Phase 2	Completed	-	China ... more >> Li Ka Shing Specialist Clinic, Prince of Wales Hospital Hong Kong (SAR), China, 852 Collapse <<
NCT02805699	Combined Pulmonary Fibrosis an... more >>d Emphysema Collapse <<	Phase 2	Recruiting	September 2019	China, Beijing ... more >> Beijing University of Chinese Medicine Third Affiliated Hospital Recruiting Beijing, Beijing, China, 100029 Contact: fei han 010-52075251 kymbxz@126.com Contact: changan li 010-52075411 lichangan1989@163.com Principal Investigator: Hongsheng Cui, Ph.D Sub-Investigator: Chang'an Li, Master Sub-Investigator: Weibo Bi, Master Sub-Investigator: Jianjun Wu, Master Sub-Investigator: Ruifeng Jin, Master Sub-Investigator: Minmin Shan, Master Sub-Investigator: Qiuyi Chen, Master Dongzhimen hospital Recruiting Beijing, Beijing, China Contact: Lishan Zhang 010-52075411 lszh111@sina.com Collapse <<
NCT03009136	Perennial Allergic Rhinitis	Phase 3	Recruiting	December 2018	Korea, Republic of ... more >> Kyung Hee University Hospital at Gangdong Recruiting Seoul, Korea, Republic of, 05278 Contact: Youme Ko, MD(TCM) 82-2-961-9278 meyougo@khu.ac.kr Principal Investigator: Minhee Kim Collapse <<
NCT03773315	Dyslipidemias	Not Applicable	Recruiting	December 31, 2019	Korea, Republic of ... more >> Integrated Research Institute for Natural Ingredients and Functional Foods Recruiting Yangsan, Korea, Republic of, 50612 Contact: Sang Yeoup Lee, MD 82-55-360-2860 saylee@pnu.edu Collapse <<
NCT01068067	Renal Transplantation	Not Applicable	Unknown	-	China, Guangdong ... more >> Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Min Huang, PhD 86-20-39943011 huangmin@mail.sysu.edu.cn Principal Investigator: Jia-Li Li, PhD Principal Investigator: Xue-Ding Wang, MD Kidney Transplant Department, Transplant Center, the First Affiliated Hospital of Sun Yat-sen University Not yet recruiting Guangzhou, Guangdong, China, 510080 Contact: Chang-Xi Wang, MD 86-20-87755766 ext 813 wcx6363@163.com Sub-Investigator: Qian Fu, MD Sub-Investigator: Long-Shan Liu, MD Collapse <<
NCT02250027	Acute Bronchitis ... more >> Acute Exacerbations of Chronic Bronchitis Collapse <<	Phase 2	Completed	-	Korea, Republic of ... more >> Kyung Hee University Hospital Seoul, Korea, Republic of, 130-872 Collapse <<
NCT01472822	-	-	Completed	-	-
NCT01006460	Depression St... more >>ress Collapse <<	Not Applicable	Completed	-	Denmark ... more >> Department of Clinical Biochemistry, Frederikbergs Hospital Frederiksberg, Denmark, 2000 Collapse <<
NCT01472822	Mild Knee Osteoarthritis	Phase 2 Phase 3	Completed	-	Korea, Republic of ... more >> Clinical Trial Center for Functional Foods; Chonbuk National University Hospital Jeonju, Jeollabuk-do, Korea, Republic of, 560-822 Collapse <<
NCT03402308	Muscular Sarcoidosis	Not Applicable	Completed	-	Korea, Republic of ... more >> Pusan National University Yangsan Hospital Pusan, Ami-dong, Korea, Republic of, 602-739 Collapse <<

五味子醇甲 Catalog No. CSN19434

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